PROCESSES FOR THE PREPARATION OF INTERMEDIATES OF RALTEGRAVIR

The present disclosure provides a process for the preparation of 2-(2-amino propan-2-yl)-N-(4-fluorobenzyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydro-pyrimidine- 4-carboxamide by debenzylation of benzyl(2-{4-[(4-fluorobenzyl)carbamoyl]-5- hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl}propan-2-yl)carba...

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Bibliographic Details
Main Authors MITCHANAGATLA, KIRAN, VELLANKI, SIVA RAM PRASAD, BALUSU, RAJA BABU
Format Patent
LanguageEnglish
French
Published 06.08.2015
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present disclosure provides a process for the preparation of 2-(2-amino propan-2-yl)-N-(4-fluorobenzyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydro-pyrimidine- 4-carboxamide by debenzylation of benzyl(2-{4-[(4-fluorobenzyl)carbamoyl]-5- hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl}propan-2-yl)carbamate. This process may be used in the synthesis of raltegravir and pharmaceutically acceptable salts thereof. La présente invention concerne un procédé pour la préparation de 2-(2-amino propan-2-yl)-N-(4-fluorobenzyl)-5-hydroxy-1-méthyl-6-oxo-1,6-dihydro-pyrimidine-4-carboxamide par débenzylation de benzyl(2-{4-[(4-fluorobenzyl)carbamoyle]-5-hydroxy-1-méthyl-6-oxo-1,6-dihydropyrimidin-2-yl}propan-2-yl)carbamate. Ce procédé peut être utilisé dans la synthèse de raltégravir et de ses sels pharmaceutiquement acceptables.
Bibliography:Application Number: WO2015IB50808