ASSISTED PARTICLE SIZE REDUCTION PROCESS

• Main Authors: VILLAX, PETER, TEMTEM, MÁRCIO, SOBRAL, LUIS, COSTA, EUNICE, CACELA, CONSTANÇA
• Format: Patent
• Language: English; French
• Published: 06.08.2015
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A new scalable process to control the particle size and the particle size distribution, comprising5 steps: (i) suspension preparation in a mixture of solvents in which the API and/or excipient is partially soluble in one of the solvents; (ii) particle size reduction of the suspension; (iii) aging; (...