ASSISTED PARTICLE SIZE REDUCTION PROCESS

A new scalable process to control the particle size and the particle size distribution, comprising5 steps: (i) suspension preparation in a mixture of solvents in which the API and/or excipient is partially soluble in one of the solvents; (ii) particle size reduction of the suspension; (iii) aging; (...

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Bibliographic Details
Main Authors VILLAX, PETER, TEMTEM, MÁRCIO, SOBRAL, LUIS, COSTA, EUNICE, CACELA, CONSTANÇA
Format Patent
LanguageEnglish
French
Published 06.08.2015
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:A new scalable process to control the particle size and the particle size distribution, comprising5 steps: (i) suspension preparation in a mixture of solvents in which the API and/or excipient is partially soluble in one of the solvents; (ii) particle size reduction of the suspension; (iii) aging; (iv)stopping the aging by solvent removal; and (v) optionally, a step of isolating the processed ingredients in the form of powder. La présente invention concerne un nouveau procédé évolutif pour contrôler la taille de particule et la granulométrie, comprenant 5 étapes : (i) préparation d'une suspension dans un mélange de solvants dans laquelle la substance active et/ou l'excipient est partiellement soluble dans un des solvants ; (ii) réduction de taille de particule de la suspension ; (iii) maturation ; (iv) arrêt de la maturation par élimination des solvants ; et (v) facultativement, une étape d'isolement des composants traités sous la forme de poudre.
Bibliography:Application Number: WO2015GB50186