ASSISTED PARTICLE SIZE REDUCTION PROCESS
A new scalable process to control the particle size and the particle size distribution, comprising5 steps: (i) suspension preparation in a mixture of solvents in which the API and/or excipient is partially soluble in one of the solvents; (ii) particle size reduction of the suspension; (iii) aging; (...
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Main Authors | , , , , |
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Format | Patent |
Language | English French |
Published |
06.08.2015
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Subjects | |
Online Access | Get full text |
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Summary: | A new scalable process to control the particle size and the particle size distribution, comprising5 steps: (i) suspension preparation in a mixture of solvents in which the API and/or excipient is partially soluble in one of the solvents; (ii) particle size reduction of the suspension; (iii) aging; (iv)stopping the aging by solvent removal; and (v) optionally, a step of isolating the processed ingredients in the form of powder.
La présente invention concerne un nouveau procédé évolutif pour contrôler la taille de particule et la granulométrie, comprenant 5 étapes : (i) préparation d'une suspension dans un mélange de solvants dans laquelle la substance active et/ou l'excipient est partiellement soluble dans un des solvants ; (ii) réduction de taille de particule de la suspension ; (iii) maturation ; (iv) arrêt de la maturation par élimination des solvants ; et (v) facultativement, une étape d'isolement des composants traités sous la forme de poudre. |
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Bibliography: | Application Number: WO2015GB50186 |