METHOD FOR SCREENING RISK OF DRUG-INDUCED TOXICITY
Provided in the present invention is a method for screening the risk of a drug-induced toxicity by using NAT2, CYP2E1 and Xanthine Oxidase genes to screen the drug-induced toxicity, in particular a method for screening the risk of anti-tuberculosis drug-induced liver damage. The method of the presen...
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Format | Patent |
Language | Chinese English French |
Published |
30.07.2015
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Abstract | Provided in the present invention is a method for screening the risk of a drug-induced toxicity by using NAT2, CYP2E1 and Xanthine Oxidase genes to screen the drug-induced toxicity, in particular a method for screening the risk of anti-tuberculosis drug-induced liver damage. The method of the present invention comprises providing a specimen to be detected and detecting at least one SNP genotype of the NAT2, CYP2E1 and Xanthine Oxidase genes in the genomic DNA of the specimen, wherein the presence of the SNP genotype indicates that the specimen being detected is at risk of suffering from an anti-tuberculosis drug-induced toxicity; and the SNP genotype is selected from at least one of the group consisting of the following genotypes: rs1041983, rs1112005, rs1495741, rs1799930, rs1799931, rs1801280, rs1961456, rs2087852, rs11996129, rs2031920, rs2249695, rs3813865, rs3813867, rs1884725, rs2295475 and rs17011368. Furthermore, the screening method of the present invention comprises providing a specimen to be detect |
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AbstractList | Provided in the present invention is a method for screening the risk of a drug-induced toxicity by using NAT2, CYP2E1 and Xanthine Oxidase genes to screen the drug-induced toxicity, in particular a method for screening the risk of anti-tuberculosis drug-induced liver damage. The method of the present invention comprises providing a specimen to be detected and detecting at least one SNP genotype of the NAT2, CYP2E1 and Xanthine Oxidase genes in the genomic DNA of the specimen, wherein the presence of the SNP genotype indicates that the specimen being detected is at risk of suffering from an anti-tuberculosis drug-induced toxicity; and the SNP genotype is selected from at least one of the group consisting of the following genotypes: rs1041983, rs1112005, rs1495741, rs1799930, rs1799931, rs1801280, rs1961456, rs2087852, rs11996129, rs2031920, rs2249695, rs3813865, rs3813867, rs1884725, rs2295475 and rs17011368. Furthermore, the screening method of the present invention comprises providing a specimen to be detect |
Author | HU, OLIVER YAO-PU HSIONG, CHENG-HUEI SHIH, TUNG-YUAN HO, HSIN-TIEN |
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Discipline | Medicine Chemistry Sciences |
DocumentTitleAlternate | PROCÉDÉ DE DÉPISTAGE D'UN RISQUE DE TOXICITÉ D'ORIGINE MÉDICAMENTEUSE 药物引发毒性的风险性筛检方法 |
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Snippet | Provided in the present invention is a method for screening the risk of a drug-induced toxicity by using NAT2, CYP2E1 and Xanthine Oxidase genes to screen the... |
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SubjectTerms | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS VINEGAR WINE |
Title | METHOD FOR SCREENING RISK OF DRUG-INDUCED TOXICITY |
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