METHOD FOR SCREENING RISK OF DRUG-INDUCED TOXICITY

• Main Authors: SHIH, TUNG-YUAN, HU, OLIVER YAO-PU, HSIONG, CHENG-HUEI, HO, HSIN-TIEN
• Format: Patent
• Language: Chinese; English; French
• Published: 30.07.2015
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPIRITS; VINEGAR; WINE

Provided in the present invention is a method for screening the risk of a drug-induced toxicity by using NAT2, CYP2E1 and Xanthine Oxidase genes to screen the drug-induced toxicity, in particular a method for screening the risk of anti-tuberculosis drug-induced liver damage. The method of the present invention comprises providing a specimen to be detected and detecting at least one SNP genotype of the NAT2, CYP2E1 and Xanthine Oxidase genes in the genomic DNA of the specimen, wherein the presence of the SNP genotype indicates that the specimen being detected is at risk of suffering from an anti-tuberculosis drug-induced toxicity; and the SNP genotype is selected from at least one of the group consisting of the following genotypes: rs1041983, rs1112005, rs1495741, rs1799930, rs1799931, rs1801280, rs1961456, rs2087852, rs11996129, rs2031920, rs2249695, rs3813865, rs3813867, rs1884725, rs2295475 and rs17011368. Furthermore, the screening method of the present invention comprises providing a specimen to be detect