SOLID ORAL DOSAGE FORM OF IRINOTECAN FOR THE TREATMENT OF CANCER

The present invention relates to a composition, in particular a solid pharmaceutical composition comprising a compound having the formula I, as a free base or a salt thereof, and a mixture comprising a vehicle and a non-ionic surfactant in an amount sufficient to achieve solubilization of compound (...

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Bibliographic Details
Main Author HØJGAARD, BENT
Format Patent
LanguageEnglish
French
Published 23.07.2015
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to a composition, in particular a solid pharmaceutical composition comprising a compound having the formula I, as a free base or a salt thereof, and a mixture comprising a vehicle and a non-ionic surfactant in an amount sufficient to achieve solubilization of compound (I); and typically wherein the composition is coated with an enteric coating. Such composition is particularly useful in treatment of cancer. La présente invention concerne une composition, en particulier une composition pharmaceutique solide comprenant un composé présentant la formule I, sous forme de base libre ou d'un sel correspondant, et un mélange comprenant un excipient et un tensioactif non ionique en une quantité suffisante pour atteindre la solubilisation du composé (I) ; et de manière caractéristique, la composition étant revêtue par un enrobage entérique. Une telle composition est particulièrement utile dans le traitement du cancer.
Bibliography:Application Number: WO2015EP50728