AQUEOUS FORMULATION OF MOXIFLOXACIN AND PREPARATION METHOD THEREFOR

• Main Authors: LEE, MIN KYOUNG, CHOI, KWANG DO, KO, JAE KYOUNG, BYUN, SANG HWAN, HONG, JOO YONG, KIM, EUN SUN
• Format: Patent
• Language: English; French; Korean
• Published: 25.06.2015
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention relates to a method for preparing an aqueous formulation of moxifloxacin and an aqueous formulation of moxifloxacin prepared thereby and, more specifically, to a method for preparing an aqueous formulation of moxifloxacin, comprising the step of dissolving moxifloxacin free base in a NaCl aqueous solution, and an aqueous formulation of moxifloxacin prepared thereby. The present invention has an effect of providing: an aqueous formulation of moxifloxacin which is suitable for mass production because the aqueous formulation of moxifloxacin exhibits excellent quality, content uniformity and accuracy without moisture absorption problems during the preparation process and storage, and because the preparation process is simple; and a method for preparing the same. La présente invention concerne une méthode de préparation d'une formulation aqueuse de moxifloxacine et la formulation aqueuse de la moxifloxacine ainsi préparée, et, plus précisément, une méthode de préparation d'une formulation aqueuse de moxifloxacine comportant une étape de dissolution de la moxifloxacine sous sa forme de base libre dans une solution aqueuse de NaCl, et la formulation aqueuse de moxifloxacine ainsi préparée. La présente invention permet d'obtenir une formulation aqueuse de la moxifloxacine adaptée à la production de masse, en raison du fait que la formulation aqueuse de moxifloxacine présente une excellente qualité, une uniformité et précision de son contenu, sans problèmes d'absorption d'humidité au cours des processus de préparation et de stockage, et que le processus de préparation est simple. La présente invention concerne également une méthode pour préparer cette formulation. 본 발명은 목시플록사신 수성 제형의 제조방법 및 이로부터 제조된 목시플록사신 수성 제형에 관한 것으로, 보다 상세하게는 NaCl 수용액에 목시플록사신 유리염기를 용해시키는 단계를 포함하여 이루어지는 목시플록사신 수성 제형의 제조방법 및 이로부터 제조된 목시플록사신 수성 제형에 관한 것이다. 본 발명에 따르면, 제조공정 및 보관 상 흡습성이 전혀 문제되지 않아 품질, 함량 균일성 및 정확도가 뛰어나고, 제조공정이 간단하여 대량 생산에 적합한 목시플록사신 수형 제형 및 이의 제조방법을 제공하는 효과가 있습니다.