FUSED IMIDAZOLE AND PYRAZOLE DERIVATIVES AS MODULATORS OF TNF ACTIVITY

• Main Authors: LECOMTE, FABIEN CLAUDE, MILLER, CRAIG ADRIAN, SELBY, MATTHEW DUNCAN, DEBOVES, HERVÉ JEAN CLAUDE, PORTER, JOHN ROBERT, MADDEN, JAMES, ALEXANDER, RIKKI PETER, VAIDYA, DARSHAN GUNVANT, BENTLEY, JONATHAN MARK, JOHNSTONE, CRAIG, CHOVATIA, PRAFUL TULSHI, SHAW, MICHAEL ALAN, JONES, ELIZABETH PEARL, BROOKINGS, DANIEL CHRISTOPHER, KROEPLIEN, BORIS, YULE, IAN ANDREW, BRACE, GARETH NEIL
• Format: Patent
• Language: English; French
• Published: 18.06.2015
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

A series of substituted benzimidazole, imidazo[1,2-a]pyridine and pyrazolo[1,5-a]pyridine derivatives, and analogues thereof, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders. La présente invention concerne une série de dérivés de benzimidazole, imidazo[1,2-a]pyridine et pyrazolo[1,5-a]pyridine substitués, et leurs analogues, puissants modulateurs de l'activité du TNF-alpha humain, qui sont donc utiles dans le traitement et/ou la prévention de diverses maladies humaines, notamment les troubles auto-immuns et inflammatoires, les troubles neurologiques et neurodégénératifs, les troubles nociceptifs et de la douleur, les troubles cardiovasculaires, les troubles métaboliques, les troubles oculaires et les troubles oncologiques.