AUTOIMMUNE ANTIGENS AND CANCER

Autoimmune diseases are thought to be initiated by exposures to foreign antigens that cross-react with endogenous molecules. Analyses of peripheral blood lymphocytes and serum suggested that mutations in autoimmune antigen targets sparked cellular immunity and cross-reactive humoral immune responses...

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Main Authors PAPADOPOULOS, NICKOLAS, SHAH, AMI A, CASCIOLA-ROSEN, LIVIA A, JOSEPH, CHRISTINE, KINZLER, KENNETH W, VOGELSTEIN, BERT, DARRAH, ERIKA, ROSEN, ANTHONY
Format Patent
LanguageEnglish
French
Published 11.06.2015
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Autoimmune diseases are thought to be initiated by exposures to foreign antigens that cross-react with endogenous molecules. Analyses of peripheral blood lymphocytes and serum suggested that mutations in autoimmune antigen targets sparked cellular immunity and cross-reactive humoral immune responses. Acquired immunity to autoimmune antigens can help control naturally occurring cancers. On pense que des maladies auto-immunes sont amorcées par l'exposition à des antigènes étrangers qui réagissent de façon croisée avec des molécules endogènes. Des analyses de lymphocytes de sang périphérique et de sérum ont suggéré que des mutations affectant des cibles d'antigènes auto-immuns ont amorcé l'immunité cellulaire et des réponses immunitaires humorales à réaction croisée. L'immunité acquise à des antigènes auto-immuns peut contribuer à la lutte contre des cancers d'origine naturelle.
Bibliography:Application Number: WO2014US68635