SYNTHESIS AND FORMULATIONS OF PORPHYRIN COMPOUNDS

Provided herein, inter alia, are methods of synthesizing and formulating porphyrins, including manganese containing porphyrins. Also provided herein are pharmaceutical compositions and crystals of porphyrins achieved using the methods described herein. In a first aspect is a method for synthesizing...

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Bibliographic Details
Main Authors BELL, DUANE, STANLEY, CHRIS, KOLCHINSKI, ALEXANDER, MIRMEHRABI, MAHMOUD, BRITTAIN, JASON
Format Patent
LanguageEnglish
French
Published 28.05.2015
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Provided herein, inter alia, are methods of synthesizing and formulating porphyrins, including manganese containing porphyrins. Also provided herein are pharmaceutical compositions and crystals of porphyrins achieved using the methods described herein. In a first aspect is a method for synthesizing a substituted porphyrin. The method includes contacting a pyrrole with a substituted aldehyde. The contacting is performed in a solvent system that includes a positive azeotrope. La présente invention concerne entre autres des procédés de synthèse et de formulation de porphyrines, y compris de porphyrines contenant du manganèse. Cette invention concerne également des compositions pharmaceutiques et des cristaux de porphyrines obtenus au moyen desdits procédés. Selon un premier aspect, l'invention se rapporte à un procédé pour synthétiser une porphyrine substituée, ce procédé consistant notamment à mettre en contact un pyrrole avec un aldéhyde sustitué. Cette mise en contact est réalisée dans un système de solvants comprenant un azéotrope positif.
Bibliography:Application Number: WO2014US66923