TETRACYCLIC HETEROCYCLE COMPOUNDS USEFUL AS HIV INTEGRASE INHIBITORS

The present invention relates to Tetracyclic Heterocycle Compounds of Formula (I) and pharmaceutically acceptable salts or prodrug thereof, wherein n, X, Y, Z, R1, R2, and R3 are as defined herein. The present invention also relates to compositions comprising at least one Tetracyclic Heterocycle Com...

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Main Authors WALJI, ABBAS, WAI, JOHN, MARCO, CHRISTINE NG DI, RAHEEM, IZZAT T, PENG, XUANJIA, HU, LIHONG, COLEMAN, PAUL, NEELAMKAVIL, SANTHOSH F
Format Patent
LanguageEnglish
French
Published 26.03.2015
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to Tetracyclic Heterocycle Compounds of Formula (I) and pharmaceutically acceptable salts or prodrug thereof, wherein n, X, Y, Z, R1, R2, and R3 are as defined herein. The present invention also relates to compositions comprising at least one Tetracyclic Heterocycle Compound, and methods of using the Tetracyclic Heterocycle Compounds for treating or preventing HIV infection in a subject. La présente invention porte sur des composés hétérocycliques tétracycliques de formule (I) et leurs sels ou promédicaments pharmaceutiquement acceptables, dans laquelle formule n, X, Y, Z, R1, R2 et R3 sont tels que définis dans la description. La présente invention porte également sur des compositions comprenant au moins un composé hétérocyclique tétracyclique et sur des procédés d'utilisation des composés hétérocycliques tétracycliques pour le traitement ou la prévention d'une infection à VIH chez un sujet.
Bibliography:Application Number: WO2013CN83998