FORM 2 CRYSTALLINE POLYMORPH OF A SALT OF N-[1-6-(ETHYNYL-3-OXO-HEXAHYDRO-FURO[3,2-B]PYRROLE-4-CARBONYL)-3-METHYL-BUTYL]-4-[5-FLUORO-2-(4-METHYL-PIPERAZINYL)THIAZOL-4-YL]-BENZAMIDE USEFUL AS CYSTEINE PROTEASE INHIBITOR

There is provided Form 2 crystalline polymorph consisting of N-[1-6-(ethynyl-3-oxo-hexahydro-furo[3,2-b]pyrrole-4-carbonyl)-3-methyl-butyl]-4-[5-fluoro-2-(4-methyl-piperazin-1-yl)thiazol-4-yl]-benzamide monohydrochloride and N-[1-6-(ethynyl-3-oxo-hexahydro-furo[3,2-b]pyrrole-4- carbonyl)-3-methyl-bu...

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Bibliographic Details
Main Authors DIAZ PEREZ, VICTOR M, CARR, ANDREW, GRABOWSKA, URSZULA, SALVADORE-ODEN, LOURDES
Format Patent
LanguageEnglish
French
Published 19.02.2015
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:There is provided Form 2 crystalline polymorph consisting of N-[1-6-(ethynyl-3-oxo-hexahydro-furo[3,2-b]pyrrole-4-carbonyl)-3-methyl-butyl]-4-[5-fluoro-2-(4-methyl-piperazin-1-yl)thiazol-4-yl]-benzamide monohydrochloride and N-[1-6-(ethynyl-3-oxo-hexahydro-furo[3,2-b]pyrrole-4- carbonyl)-3-methyl-butyl]-4-[5-fluoro-2-(4-methyl-piperazin-1-yl)thiazol-4-yl]-benzamide hydrate monohydrochloride, its use as a medicament and methods for its preparation. L'invention porte sur la forme cristalline polymorphe 2 constituée de monochlorhydrate de N-[1-6-(éthynyl-3-oxo-hexahydrofuro[3,2-b]pyrrole-4-carbonyl)-3-méthylbutyl]-4-[5-fluoro-2-(4-méthylpipérazin-1-yl)thiazol-4-yl]benzamide et de monochlorhydrate de N-[1-6-(éthynyl-3-oxo-hexahydrofuro[3,2-b]pyrrole-4-carbonyl)-3-méthylbutyl]-4-[5-fluoro-2-(4-méthylpipérazin-1-yl)thiazol-4-yl]benzamide hydraté, sur son utilisation en tant que médicament et sur des procédés pour sa préparation.
Bibliography:Application Number: WO2014EP67374