TRICYCLIC PYRI DO-CARBOXAM I D E DERIVATIVES AS ROCK INHIBITORS

The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising th...

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Bibliographic Details
Main Authors WANG, CAILAN, PATIL, SHARANABASAPPA, QUAN, MIMI L, HU, ZILUN
Format Patent
LanguageEnglish
French
Published 08.01.2015
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same. La présente invention concerne des composés de formule (I) : ou leurs stéréoisomères, tautomères, ou sels pharmaceutiquement acceptables, toutes les variables étant telles que définies dans la description. Ces composés sont des inhibiteurs sélectifs de la voie ROCK. Cette invention concerne également des compositions pharmaceutiques comprenant ces composés et des procédés de traitement de troubles cardiovasculaires, des muscles lisses, oncologiques, neuropathologiques, auto-immuns, fibrotiques, et/ou inflammatoires les utilisant.
Bibliography:Application Number: WO2014US44988