SUBSTITUTED TRIAZOLOPYRIDINES HAVING ACTIVITY AS MPS-1 INHIBITORS

• Main Authors: LIENAU, PHILIP, SIEMEISTER, GERHARD, STÖCKIGT, DETLEF, SCHULZE, VOLKER K, BRIEM, HANS, SCHALL, ANDREAS, WENGNER, ANTJE MARGRET
• Format: Patent
• Language: English; French
• Published: 11.12.2014
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to substituted triazolopyridine compounds of general formula (I), in which R1, R2, R3, R4, and R5 are as given in the description and in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, as well as to intermediate compounds useful in the preparation of said compounds. La présente invention concerne des composés triazolopyridine substituée de formule générale (I), dans laquelle R1, R2, R3, R4, et R5 sont tels que présentés dans la description et dans les revendications, des procédés de préparation desdits composés, des compositions pharmaceutiques et des combinaisons comprenant lesdits composés, l'utilisation desdits composés pour la fabrication d'une composition pharmaceutique pour le traitement ou la prophylaxie d'une maladie, ainsi que des composés intermédiaires utiles dans la préparation desdits composés.