LAPATINIB SALTS

Disclosed are new lapatinib salts and polymorphic forms thereof and processes for their preparation. More specifically disclosed are new salts of lapatinib, namely lapatinib salts formed by (1S)-(+)-camphorsulfonic acid, 2,5 dihydroxy benzoic acid, hydrogen bromide, malonic acid, naphtalene 1,5 disu...

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Main Authors HÉDER, JÁNOS LEVENTE, MÁRVÁNYOS, EDE, VARGA, ZOLTÁN, VOLK, BALÁZS, LUKÁCS, GYULA, GREGOR, TAMÁS, DANCSÓ, ANDRÁS, TÓTHNÉ LAURITZ, MÁRIA, PALOTAI, LÁSZLÓ, PONGÓ, LÁSZLÓ
Format Patent
LanguageEnglish
French
Published 14.05.2015
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Disclosed are new lapatinib salts and polymorphic forms thereof and processes for their preparation. More specifically disclosed are new salts of lapatinib, namely lapatinib salts formed by (1S)-(+)-camphorsulfonic acid, 2,5 dihydroxy benzoic acid, hydrogen bromide, malonic acid, naphtalene 1,5 disulfonic acid, naphtalene 2 sulfonic acid, nitric acid, citric acid and hydrochloric acid. L'invention concerne de nouveaux sels de lapatinibe ainsi que leurs formes polymorphes, et des processus de préparation de ces derniers. L'invention concerne plus précisément de nouveaux sels de lapatinibe formés par de l'acide (1S)-(+)-camphorsulfonique, de l'acide 2,5 dihydroxybenzoïque, du bromure d'hydrogène, de l'acide malonique, de l'acide naphtalène-1,5-disulfonique, de l'acide naphtalène-2-sulfonique, de l'acide nitrique, de l'acide citrique et de l'acide chlorhydrique.
Bibliography:Application Number: WO2014HU00047