PROCESS FOR THE PREPARATION OF BORTEZOMIB MANNITOL ESTER

A novel and improved process for preparation of bortezomib mannitol ester is derived, which process avoids excessive use of solvents, involves convenient, industrially feasible and economical techniques, and provides improvements in purity over processes known in the art. L'invention porte sur...

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Main Authors RAO, DHARMARAJ, RAMACHANDRA, KANKAN, RAJENDRA, NARAYANRAO, PATHI, SRINIVAS, LAXMINARAYAN, PUPPALA, RAVIKUMAR
Format Patent
LanguageEnglish
French
Published 18.12.2014
Subjects
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:A novel and improved process for preparation of bortezomib mannitol ester is derived, which process avoids excessive use of solvents, involves convenient, industrially feasible and economical techniques, and provides improvements in purity over processes known in the art. L'invention porte sur un nouveau procédé perfectionné pour la préparation d'ester de mannitol du bortézomib, lequel procédé évite l'utilisation excessive de solvants, met en jeu des techniques commodes, industriellement faisables et économiques et permet d'obtenir des améliorations en termes de pureté par rapport à des procédés connus dans l'état antérieur de la technique.
Bibliography:Application Number: WO2014GB00150