MODIFIED PROTEINS AND METHODS OF USE THEREOF

This invention is generally related to small proteins, such as miniature proteins, including avian pancreatic polypeptide (aPP), modified so that the small proteins reach the cytosol. In some embodiments, the modified protein molecules deliver an associated cargo molecule to the cytosol. Other embod...

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Bibliographic Details
Main Authors SCHEPARTZ, ALANNA, S, LAROCHELLE, JONATHAN, R, APPELBAUM, JACOB, S
Format Patent
LanguageEnglish
French
Published 16.10.2014
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:This invention is generally related to small proteins, such as miniature proteins, including avian pancreatic polypeptide (aPP), modified so that the small proteins reach the cytosol. In some embodiments, the modified protein molecules deliver an associated cargo molecule to the cytosol. Other embodiments of the invention relate to modified protein fusion molecules that reach the cytosol. Cette invention concerne en général des petites protéines, telles que des protéines miniatures, comprenant un polypeptide pancréatique aviaire (aPP) modifié de sorte que les petites protéines atteignent le cytosol. Dans certains modes de réalisation, les molécules protéiques modifiées administrent une molécule cargo, associée au cytosol. D'autres modes de réalisation de l'invention concernent des molécules de fusion de protéines modifiées qui atteignent le cytosol.
Bibliography:Application Number: WO2014US34003