ANTIBODIES AND METHODS OF DETECTION

• Main Authors: BROWN II, CHARLES, ROBERT, ROBBINS, PAUL, BRIAN, LEWIS, ARTHUR, RICHARD, LAVALLEE, THERESA, MARIE, REBELATTO, MARLON, CEZAR, AUSTIN, MARK, JULIAN
• Format: Patent
• Language: English; French
• Published: 09.10.2014
• Subjects: CHEMISTRY; COMBINATORIAL CHEMISTRY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; TESTING

Disclosed herein are methods for detecting surface expressed proteins, for example, B7 family members such as PD-L1. Also disclosed are antibodies and antibody fragments that specifically bind PD-L1 and methods for generating antibodies and antibody fragments that specifically bind PD-L1. Cette invention concerne des procédés de détection de protéines exprimées à la surface, par exemple, des membres de la famille B7 tels que PD-L1. Des anticorps et des fragments d'anticorps qui se lient spécifiquement à PD-L1 et des procédés de génération d'anticorps et de fragments d'anticorps qui se lient spécifiquement à PD-L1 sont en outre décrits.