COUMARIN DERIVATIVES AND METHODS OF USE IN TREATING HYPERPROLIFERATIVE DISEASES

Coumarin derivative compounds and methods for the treatment of hyperproliferative diseases, such as cancer, polycystic kidney disease, and fibrosis of different tissues (e.g., idiopathic pulmonary fibrosis), are provided. The methods include administering to a subject a compound as described herein....

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Main Authors RITCHIE, JOSEPH P, DIXON, JOHN, GAO, HONGWU, SEALES, ERIC, C, MAI, DEBORAH, SCHWIEBERT, ERIK, STREIFF, JOHN
Format Patent
LanguageEnglish
French
Published 13.11.2014
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Coumarin derivative compounds and methods for the treatment of hyperproliferative diseases, such as cancer, polycystic kidney disease, and fibrosis of different tissues (e.g., idiopathic pulmonary fibrosis), are provided. The methods include administering to a subject a compound as described herein. Also provided are methods for inhibiting the interaction between two or more heat shock protein chaperones in a cell. L'invention concerne des composés de dérivé de coumarine et des méthodes de traitement de maladies hyperprolifératives, telles que le cancer, la maladie polykystique des reins, et la fibrose de différents tissus (par exemple, la fibrose pulmonaire idiopathique). Les méthodes comprennent l'administration à un sujet d'un composé tel que décrit ici. L'invention concerne également des méthodes permettant d'inhiber l'interaction entre au moins deux chaperons de protéine de choc thermique dans une cellule.
Bibliography:Application Number: WO2014US27154