MONOCLONAL ANTIBODY INHIBITING ENZYMATIC ACTIVITY OF ENDOTHELIAL LIPASE

• Main Authors: MAEKAWA, KAZUHIKO, TSUKAMOTO, TASUKU, ONODA, JUNJI, NUMATA, YOSHITO, YAMANE, SHOJI, NAITO, SHOICHI, YAMADA, KATSUTOSHI, TAKAHASHI, TATSUYA
• Format: Patent
• Language: English; French; Japanese
• Published: 18.09.2014
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

Provided are a monoclonal antibody or a fragment thereof which is effective in the treatment of arteriosclerosis and metabolic syndrome and selectively inhibits endothelial lipase activity, and a pharmaceutical composition including the same as an active component. L'invention concerne un anticorps monoclonal ou un fragment de celui-ci qui est efficace dans le traitement de l'artériosclérose et d'un syndrome métabolique, et qui inhibe de façon sélective l'activité lipase endothéliale, et une composition pharmaceutique comprenant celui-ci comme composant actif.