THIENO[3,2-D]PYRIMIDINE-6-CARBOXAMIDES AND ANALOGUES AS SIRTUIN MODULATORS

Provided herein are novel substituted thieno[3,2-d]pyrimidine-6-carboxamide sirtuin inhibitors and methods of use thereof. The sirtuin inhibitors may be used for inhibiting a sirtuin-mediated biological process, and, e.g. for treating and/or preventing diseases and disorders including, but not limit...

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Bibliographic Details
Main Authors BLUM, CHARLES, A, PERNI, ROBERT, B, DISCH, JEREMY, S, EVINDAR, GHOTAS
Format Patent
LanguageEnglish
French
Published 12.09.2014
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Provided herein are novel substituted thieno[3,2-d]pyrimidine-6-carboxamide sirtuin inhibitors and methods of use thereof. The sirtuin inhibitors may be used for inhibiting a sirtuin-mediated biological process, and, e.g. for treating and/or preventing diseases and disorders including, but not limited to cancer, neurodegenerative disease and inflammation. Also provided herein are pharmaceutical compositions comprising these sirtuin inhibitors and compositions comprising a sirtuin inhibitor in combination with another therapeutic agent. L'invention concerne de nouveaux inhibiteurs de sirtuine de type thiéno[3,2-d]pyrimidine-6-carboxamide substitué et des procédés pour les utiliser. Les inhibiteurs de sirtuine peuvent être utilisés pour inhiber un processus biologique médié par une sirtuine, et, par exemple, pour traiter et/ou prévenir des maladies et des troubles, comprenant, sans s'y limiter, le cancer, une maladie neurodégénérative et une inflammation. L'invention concerne également des compositions pharmaceutiques comprenant ces inhibiteurs de sirtuine et des compositions comprenant un inhibiteur de sirtuine en combinaison avec un autre agent thérapeutique.
Bibliography:Application Number: WO2014US21683