COMPOUNDS INHIBITING LEUCINE-RICH REPEAT KINASE ENZYME ACTIVITY

• Main Authors: TEMPEST, PAUL, BASU, KALLOL, SCOTT, JACK, DEMONG, DUANE, LI, WEI, STAMFORD, ANDREW, POIRIER, MARC, MILLER, MICHAEL
• Format: Patent
• Language: English; French
• Published: 12.09.2014
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention is directed to indazole compounds which are potent inhibitors of LRRK2 kinase and useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK-2 kinase is involved. La présente invention concerne des composés indazoles qui sont de puissants inhibiteurs de la kinase LRRK2 et utiles dans le traitement ou la prévention de maladies dans lesquelles la kinase LRRK2 est impliquée, tel que la maladie de Parkinson. L'invention concerne également des compositions pharmaceutiques comprenant lesdits composés et l'utilisation de ces composés et compositions dans la prévention ou le traitement de telles maladies dans lesquelles la kinase LRRK2 est impliquée.