COMPOUNDS INHIBITING LEUCINE-RICH REPEAT KINASE ENZYME ACTIVITY

• Main Authors: HARRIS, JOEL, TEMPEST, PAUL, BASU, KALLOL, SCOTT, JACK, DEMONG, DUANE, LI, WEI, STAMFORD, ANDREW, POIRIER, MARC, MILLER, MICHAEL
• Format: Patent
• Language: English; French
• Published: 12.09.2014
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention is directed to indazole compounds which are potent inhibitors of LRRK2 kinase and useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK-2 kinase is involved. La présente invention concerne des composés indazole, lesquels sont de puissants inhibiteurs de la kinase LRRK2 et sont utiles pour traiter ou prévenir des maladies dans lesquelles la kinase LRRK2 est impliquée, par exemple, la maladie de Parkinson. Cette invention concerne également des compositions pharmaceutiques contenant ces composés, et l'utilisation de ces composés et compositions pour prévenir ou traiter les maladies dans lesquelles la kinase LRRK-2 est impliquée.