PHENYLPYRAZOLE DERIVATIVES AS POTENT ROCK1 AND ROCK2 INHIBITORS

The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising th...

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Bibliographic Details
Main Authors WANG, CAILAN, QUAN, MIMI L, HU, ZILUN, GLUNZ, PETER W
Format Patent
LanguageEnglish
French
Published 04.09.2014
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same. La présente invention concerne des composés de formule (I) ou des stéréo-isomères, des tautomères ou des sels de qualité pharmaceutique de ceux-ci, toutes les variables ayant la signification indiquée dans la description. Ces composés sont des inhibiteurs sélectifs des kinases ROCK. L'invention concerne également des compositions pharmaceutiques qui comprennent ces composés ainsi que des méthodes de traitement de troubles cardiovasculaires, des muscles lisses, oncologiques, neuropathologiques, auto-immuns, fibrotiques, et/ou inflammatoires au moyen desdites compositions.
Bibliography:Application Number: WO2014US19237