TRISUBSTITUTED HETEROCYCLIC DERIVATIVES AS ROR GAMMA MODULATORS

The present invention provides trisubstituted heterocyclic derivatives of formula (I), which may be therapeutically useful, more particularly as RORγ modulators; (I) in which R1, R2, R3, Ra, X, L, m and ring A have the meanings given in the specification, and pharmaceutically acceptable salts thereo...

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Bibliographic Details
Main Authors HOSAHALLI, SUBRAMANYA, MAHALINGAM, NATARAJAN, BEJUGAM, MALLESHAM
Format Patent
LanguageEnglish
French
Published 21.08.2014
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention provides trisubstituted heterocyclic derivatives of formula (I), which may be therapeutically useful, more particularly as RORγ modulators; (I) in which R1, R2, R3, Ra, X, L, m and ring A have the meanings given in the specification, and pharmaceutically acceptable salts thereof that are useful in the treatment and prevention of diseases or disorder, in particular their use in diseases or disorder where there is an advantage in modulating RORγ receptor. The present invention also provides preparation of the compounds and pharmaceutical formulations comprising at least one of the trisubstituted heterocyclic derivatives of formula (I) together with a pharmaceutically acceptable carrier, diluent or excipient therefor. La présente invention concerne des dérivés hétérocycliques trisubstitués de formule (I), qui peuvent être utiles sur le plan thérapeutique, plus particulièrement en tant que modulateurs de RORγ ; (I) dans laquelle R1, R2, R3, Ra, X, L, m et le cycle A ont les significations proposées dans la description, et leurs sels pharmaceutiquement acceptables qui sont utiles dans le traitement et la prévention de maladies ou de troubles, en particulier leur utilisation dans des maladies ou des troubles dans lesquels la modulation du récepteur RORγ est avantageuse. La présente invention concerne en outre un procédé de préparation des composés et des formulations pharmaceutiques comprenant au moins l'un des dérivés hétérocycliques trisubstitués de formule (I) conjointement à un vecteur, un diluant ou un excipient pharmaceutiquement acceptables de celles-ci.
Bibliography:Application Number: WO2014IB58957