BIODEGRADABLE AND CLINICALLY-COMPATIBLE NANOP ARTICLES AS DRUG DELIVERY CARRIERS

The present invention relates to the composition of a nanoparticle based on a magnesium salt, and methods of drug delivery using the nanoparticle. A preferred embodiment uses magnesium phosphate, with or without a shell to deliver aiRNA and/or siRNA. The nanoparticles of the present invention are al...

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Bibliographic Details
Main Authors LI, YOUZHI, SAXENA, VAIBHAV, LI, CHIANG, J, DODWADKAR, NAMITA, GADA, KEYUR, PRATA, JOSEPH, DAI, XIAOSHU
Format Patent
LanguageEnglish
French
Published 14.08.2014
Subjects
CHEMISTRY
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SUGARS
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Summary:The present invention relates to the composition of a nanoparticle based on a magnesium salt, and methods of drug delivery using the nanoparticle. A preferred embodiment uses magnesium phosphate, with or without a shell to deliver aiRNA and/or siRNA. The nanoparticles of the present invention are also effective when administered orally. La présente invention concerne la composition d'une nanoparticule à base de sel de magnésium, et des procédés d'administration de médicament utilisant la nanoparticule. Un mode de réalisation préféré utilise le phosphate de magnésium, avec ou sans une enveloppe pour délivrer un ARNai et/ou un ARNsi. Les nanoparticules de la présente invention sont également efficaces lorsqu'elles sont administrées par voie orale.
Bibliography:Application Number: WO2014US14751