NITROXYL DONORS WITH IMPROVED THERAPEUTIC INDEX

The disclosed subject matter provides N-substituted hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the disclosed subject matter provides methods of using such compo...

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Bibliographic Details
Main Authors BROOKFIELD, FREDERICK ARTHUR, FROST, LISA MARIE, KALISH, VINCENT JACOB, COURTNEY, STEPHEN MARTIN
Format Patent
LanguageEnglish
French
Published 24.07.2014
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The disclosed subject matter provides N-substituted hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the disclosed subject matter provides methods of using such compounds or pharmaceutical compositions for treating heart failure. L'invention concerne des composés dérivés d'hydroxylamine à substitution N, des compositions pharmaceutiques et des kits comprenant ces composés, ainsi que des méthodes consistant à utiliser ces composés ou compositions pharmaceutiques. En particulier, l'invention concerne des méthodes consistant à utiliser ces composés ou compositions pharmaceutiques pour traiter l'insuffisance cardiaque.
Bibliography:Application Number: WO2014US12085