SUBSTITUTED IMIDAZOPYRIDINES AS HDM2 INHIBITORS

• Main Authors: MARTINEZ, MICHELLE, VOSS, MATTHEW, E, CHRISTOPHER, MATTHEW, P, GHOSH, PARTHA, PANDA, JAGANNATH, SUN, BINYUAN, BOGEN, STEPHANE, L, BOLISETTI, RAGHU, ALTMAN, MICHAEL, D, THOMPSON, CHRISTOPHER FRANCIS, CAMMARANO, CAROLYN MICHELE, SAMALA, JAYA PRAKASH, SHIZUKA, MANAMI, TROTTER, B. WESLEY, REUTERSHAN, MICHAEL HALE, MACHACEK, MICHELLE, YANG, LIPING, FRADERA LLINAS, FRANCESC XAVIER, DOLL, RONALD, J, TONY KURISSERY, ANTHAPPAN
• Format: Patent
• Language: English; French
• Published: 26.06.2014
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention provides substituted imidazopyridines as described herein or a pharmaceutically acceptable salt or solvate thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same. La présente invention concerne des imidazopyridines substituées telles que décrites dans la description ou un sel ou solvate pharmaceutiquement acceptable correspondant. Les composés représentatifs sont utiles en tant qu'inhibiteurs de la protéine HDM2. La présente invention concerne également des compositions pharmaceutiques comprenant les composés précités et des méthodes de traitement potentielles du cancer au moyen desdites compositions.