PYRIMIDINE-2,4-DIAMINE DERIVATIVES AS KINASE INHIBITORS

• Main Authors: HOSAHALLI, SUBRAMANYA, SRIKANTH, CHITTY, VENKATA, THUNUGUNTLA, SIVA, SANJEEVA, RAO
• Format: Patent
• Language: English; French
• Published: 19.06.2014
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present application relates to novel Pyrimidine-2,4-diamine derivatives as kinase inhibitors derivatives of formula (I), as protein kinase inhibitors. Formula (I). The invention particularly relates to compounds of formula (I), preparation of compounds and pharmaceutical compositions thereof. The invention further relates to prodrugs, derivatives, polymorphs, pharmaceutically acceptable salts and compositions comprising the said novel Pyrimidine-2,4-diamine derivatives as kinase inhibitors and their derivatives and their use in the treatment of various disorders. La présente invention concerne de nouveaux dérivés de pyrimidine-2,4-diamine en tant que dérivés inhibiteurs de kinase de dérivés de formule (I), en tant qu'inhibiteurs de protéine kinase. Formule (I). L'invention concerne en particulier des composés de formule (I), la préparation des composés et des compositions pharmaceutiques de ceux-ci. L'invention concerne en outre des promédicaments, des dérivés, des polymorphes, des sels pharmaceutiquement et des compositions comprenant lesdits nouveaux dérivés de pyrimidine-2,4-diamine en tant qu'inhibiteurs de kinase et leurs dérivés et leur utilisation dans le traitement de différents troubles.