BLOOD-BRAIN BARRIER (BBB) PENETRATING DUAL SPECIFIC BINDING PROTEINS

Engineered multivalent and multispecific binding proteins capable of penetrating the blood-brain barrier (BBB) are provided, along with methods of making and uses in the prevention, diagnosis, and/or treatment of disease. L'invention concerne des protéines de liaison multivalentes et multi-spéc...

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Main Authors HANZATIAN, DENISE, KARAOGLU, STERMAN, ANNETTE, J., SCHWARTZ, GHAYUR, TARIQ, GOODEARL, ANDREW, HARRIS, MARIA, CRISTINA
Format Patent
LanguageEnglish
French
Published 12.06.2014
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Engineered multivalent and multispecific binding proteins capable of penetrating the blood-brain barrier (BBB) are provided, along with methods of making and uses in the prevention, diagnosis, and/or treatment of disease. L'invention concerne des protéines de liaison multivalentes et multi-spécifiques génétiquement modifiées capables de pénétrer la barrière hémato-encéphalique (BBB), ainsi que des procédés de fabrication et des utilisations dans la prévention, le diagnostic et/ou le traitement d'une maladie.
Bibliography:Application Number: WO2013US73114