GLUCOPYRANOSYL DERIVATIVE, PREPARATION METHOD AND MEDICAL USE THEREOF

• Main Authors: YUAN, MINGYUN, WU, WUYONG, WEN, JIAPING, GU, ZHENG, TANG, PENG CHO, LU, YONGHUA, ZHU, GUOZHI, LAN, CHENGSHENG, QIU, GUANPENG, WANG, YINCAI, WANG, HERAN, ZHANG, ZONGYUAN, CHEN, GANG, KANG, PANPAN, SU, GUIZHUAN, YE, KANGZHI, WEI, YONGGANG
• Format: Patent
• Language: Chinese; English; French
• Published: 12.06.2014
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to a C-aryl substituted glucopyranosyl derivative as an inhibitor of sodium dependent glucose transporter (SGLTs), the preparation method and the medical use thereof, in particular the glucopyranosyl derivative shown as general formula (I) or pharmaceutically acceptable salts or all stereoisomers thereof, the preparation method or pharmaceutical compositions containing the derivative and the use for treating diabetes and related diseases, wherein the definition of each substituent in general formula (I) is the same as that in the description. L'invention porte sur un dérivé glucopyranosylique C-aryle-substitué utilisé comme inhibiteur du transporteur du glucose sodium-dépendant (SGLT), sur son procédé de préparation et sur son utilisation médicale, en particulier sur le dérivé glucopyranosylique représenté par la formule générale (I) ou des sels pharmaceutiquement acceptables de celui-ci ou tous les stéréoisomères de celui-ci, sur le procédé de préparation du dérivé ou sur des compositio