IMPROVED CULTIVATION MEDIA AND PROCESS FOR IMPROVED PROTEIN PRODUCTION BY PICHIA STRAINS
The present invention provides optimized cell culture media and fed-batch cultivation processes to improve the viability and volumetric production of heterologous proteins in Pichia. The disclosed media and processes utilize a non-fermentable sugar or sugar alcohol as an osmoprotectant to improve th...
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Main Authors | , , , , , , |
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Format | Patent |
Language | English French |
Published |
05.06.2014
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Subjects | |
Online Access | Get full text |
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Summary: | The present invention provides optimized cell culture media and fed-batch cultivation processes to improve the viability and volumetric production of heterologous proteins in Pichia. The disclosed media and processes utilize a non-fermentable sugar or sugar alcohol as an osmoprotectant to improve the robustness of Pichia production strains during methanol inducible fermentation.
La présente invention concerne des milieux de culture de cellules optimisés et des procédés de culture semi-discontinus pour améliorer la viabilité et la production volumétrique de protéines hétérologues dans Pichia. Les médias et les procédés décrits utilisent un sucre ou polyol non fermentable en tant qu'osmoprotecteur pour améliorer la robustesse de souches de production de Pichia au cours d'une fermentation inductible par le méthanol. |
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Bibliography: | Application Number: WO2013US71372 |