COMPOUNDS FOR USE IN THE TREATMENT OF PARASITIC DISEASES

• Main Authors: LAUFER, RALPH, HARPER, STEVEN, BRESCIANI, ALBERTO, MONTEAGUDO, EDITH, SUMMA, VINCENZO, FERRIGNO, FEDERICA, MALANCONA, SAVINA, PONZI, SIMONA, PAONESSA, GIACOMO, ONTORIA ONTORIA, JESUS MARIA, NIZI, EMANUELA, ALTAMURA, SERGIO, BIANCOFIORE, ILARIA, ORSALE, MARIA VITTORIA, VENEZIANO, MARIA
• Format: Patent
• Language: English; French
• Published: 08.05.2014
• Subjects: CHEMISTRY; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS; TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE; TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE

The present invention relates to compounds useful for treating parasitic diseases, which are infectious diseases caused or transmitted by a parasite. Compounds of the invention are particularly active against the causative pathogens in malaria. Such compounds are selective inhibitors of parasitic histone deacetylase (PfHDAC) and suppress the growth of parasites, such as Plasmodium falciparum, at a lower concentration than the concentration required for the inhibition of the growth of mammalian cells. La présente invention concerne des composés utiles dans le traitement de maladies parasitaires qui sont des maladies infectieuses provoquées ou transmises par un parasite. Les composés de l'invention sont particulièrement actifs contre les agents pathogènes causatifs dans la malaria. Ces composés sont des inhibiteurs sélectifs de l'histone désacétylase (Pf HDAC) chez les parasites et suppriment la prolifération de parasites, tels que Plasmodium falciparum, à une concentration inférieure à la concentration requise dans l'inhibition de la prolifération de cellules mammaliennes.