METHODS FOR THE PREPARATION OF INDACATEROL AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF

The invention relates to new and improved processes for the preparation of Indacaterol and pharmaceutically acceptable salts thereof as well as intermediates for the preparation of Indacaterol. The new process avoids the use of the epoxide compound known in the art and the impurities associated ther...

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Main Authors NIETO, JAVIER GALLO, BONDE-LARSEN, ANTONIO LORENTE, SAINZ, YOLANDA FERNANDEZ, RETUERTO, JESUS IGLESIAS
Format Patent
LanguageEnglish
French
Published 27.03.2014
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention relates to new and improved processes for the preparation of Indacaterol and pharmaceutically acceptable salts thereof as well as intermediates for the preparation of Indacaterol. The new process avoids the use of the epoxide compound known in the art and the impurities associated therewith and results in a higher yield. L'invention porte sur de nouveaux procédés améliorés de préparation d'indacatérol et de sels pharmaceutiquement acceptables de celui-ci ainsi que sur des intermédiaires de préparation d'indacatérol. Le nouveau procédé évite l'utilisation du composé époxyde connu dans l'art et les impuretés associées à celui-ci et a pour résultat un rendement de production plus élevé.
Bibliography:Application Number: WO2013EP68618