DIHYDROPYRIDONE P1 AS FACTOR XIA INHIBITORS

The present invention provides compounds of Formula (VIII): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention...

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Bibliographic Details
Main Authors GILLIGAN, PAUL J, CORTE, JAMES R, EWING, WILLIAM R, YANG, WU, WANG, YUFENG, PINTO, DONALD J.P. PINTO
Format Patent
LanguageEnglish
French
Published 06.02.2014
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention provides compounds of Formula (VIII): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same. La présente invention concerne des composés de formule (VIII) : ou leurs stéréoisomères, tautomères, ou sels pharmaceutiquement acceptables, dans laquelle toutes les variables sont telles que définies dans ce document. Ces composés sont des inhibiteurs sélectifs du facteur XIa ou des inhibiteurs doubles du FXIa et de la kallikréine plasmatique. Cette invention concerne également des compositions pharmaceutiques comprenant ces composés et des méthodes de traitement de troubles thromboemboliques et/ou inflammatoires utilisant lesdits composés.
Bibliography:Application Number: WO2013US53414