LIPOSOMAL COMPOSITIONS OF EPOXYKETONE-BASED PROTEASOME INHIBITORS

Liposomal compositions comprising peptide epoxyketone compounds are described, as well as methods of making and using such liposomal compositions. These liposomal compositions provide prolonged drug exposure (relative to non-liposomal compositions comprising peptide epoxyketone compounds) without si...

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Main Authors KIRK, CHRISTOPHER, JUSTIN, WANG, ZHENGPING, CHU, KATHERINE, A, CHAN, ELENA, T, FANG, YING, JIANG, JING, JONES, JEFFREY, JOSEPH, MUCHAMUEL, TONY, MARCEL, JUMAA, MOUHANNAD
Format Patent
LanguageEnglish
French
Published 23.01.2014
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Liposomal compositions comprising peptide epoxyketone compounds are described, as well as methods of making and using such liposomal compositions. These liposomal compositions provide prolonged drug exposure (relative to non-liposomal compositions comprising peptide epoxyketone compounds) without significantly affecting biodistribution of the drug. Tolerability of peptide epoxyketone compounds was also enhanced when formulated in the liposomal compositions. La présente invention concerne des compositions liposomales contenant des composés de type peptides époxycétones, ainsi que les procédés de fabrication et d'utilisation desdites compositions liposomales. Ces compositions liposomales assurent une exposition prolongée au médicament (par rapport aux compositions non liposomales contenant des composés de type peptides époxycétones) sans affecter de façon significative la biodistribution du médicament. La formulation en compositions liposomales améliore la tolérabilité des composés de type peptides époxycétones.
Bibliography:Application Number: WO2013US50853