PROCESSES FOR THE PREPARATION OF 3,5-DISUBSTITUTED-1,2,4-OXADIAZOLES

Provided herein are processes for the preparation of 3,5-disubstituted-1,2,4-oxadiazoles and salts thereof comprising reacting a N-hydroxyamidine with an acyl chloride in a reaction mixture comprising a water-immiscible organic solvent and an aqueous base at relatively low reaction temperatures. L&#...

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Bibliographic Details
Main Authors MILLER, WILLIAM HAROLD, GRAHAM, CHARLES RICHARD, BROWN, DAVID LOUIS
Format Patent
LanguageEnglish
French
Published 09.01.2014
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Provided herein are processes for the preparation of 3,5-disubstituted-1,2,4-oxadiazoles and salts thereof comprising reacting a N-hydroxyamidine with an acyl chloride in a reaction mixture comprising a water-immiscible organic solvent and an aqueous base at relatively low reaction temperatures. L'invention concerne des procédés de préparation de 1,2,4-oxadiazoles 3,5-disubstitués et de leurs sels, comprenant la réaction d'une N-hydroxyamidine avec un chlorure d'acyle dans un mélange réactionnel comprenant un solvant organique non miscible à l'eau et une base aqueuse à des températures de réaction relativement basses.
Bibliography:Application Number: WO2013US49060