CARBAZOLE-CONTAINING SULFONAMIDES AS CRYPTOCHROME MODULATORS
The subject matter herein is directed to carbazole-containing sulfonamide derivatives and pharmaceutically acceptable salts or hydrates thereof of structural formula I wherein the variable R1, R2, R3, R4, R5, R6, R7, A, B, C, D, E, F, G, H, a, and b are accordingly described. Also provided are pharm...
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Main Authors | , |
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Format | Patent |
Language | English French |
Published |
14.11.2013
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Subjects | |
Online Access | Get full text |
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Summary: | The subject matter herein is directed to carbazole-containing sulfonamide derivatives and pharmaceutically acceptable salts or hydrates thereof of structural formula I wherein the variable R1, R2, R3, R4, R5, R6, R7, A, B, C, D, E, F, G, H, a, and b are accordingly described. Also provided are pharmaceutical compositions comprising the compounds of formula I to treat a Cry-mediated disease or disorder, such as diabetes, obesity, metabolic syndrome, Cushing' s syndrome, and glaucoma.
La présente invention concerne des dérivés de sulfonamide contenant du carbazole et des sels pharmaceutiquement acceptables ou hydrates de ceux-ci de formule structurale I dans laquelle les variables R1, R2, R3, R4, R5, R6, R7, A, B, C, D, E, F, G, H, a, et b sont respectivement décrites. La présente invention concerne en outre des compositions pharmaceutiques comprenant les composés de formule I pour traiter une maladie ou un trouble médié par Cry, tel que le diabète, l'obésité, le syndrome métabolique, le syndrome de Cushing, et le glaucome. |
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Bibliography: | Application Number: WO2013US40604 |