1-(DIHYDRONAPHTHALENYL)PYRIDONES AS MELANIN-CONCENTRATING HORMONE RECEPTOR 1 ANTAGONISTS

This invention relates to novel 1-(dihydronaphthalenyl)pyridones which are antagonists of the melanin-concentrating hormone receptor 1 (MCHR1), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the treatment of obesity and diabetes. L...

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Main Authors YUAN, JIANGXING, LV, MAOYUN, YU, HAIYU, XU, SHANLI, YAO, CHEN, GAO, MIN, QIN, DONGHUI, WU, CHENGDE, HUANG, XING, CHRISTENSEN, IV, SIEGFRIED BENJAMIN, LIN, XIAOJUAN, LI, LEI, ZHANG, ZHILIU
Format Patent
LanguageEnglish
French
Published 14.11.2013
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:This invention relates to novel 1-(dihydronaphthalenyl)pyridones which are antagonists of the melanin-concentrating hormone receptor 1 (MCHR1), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the treatment of obesity and diabetes. L'invention concerne de nouvelles 1-(dihydronaphtalényl)pyridones qui sont des antagonistes du récepteur 1 de l'hormone de concentration de la mélanine (MCHR1), des compositions pharmaceutiques les contenant, leurs procédés de préparation et leur utilisation en thérapie pour le traitement de l'obésité et du diabète.
Bibliography:Application Number: WO2012CN00628