GLUFOSFAMIDE COMBINATION THERAPIES FOR CANCER

• Main Authors: PARRIS, MATTHEW, ANTHONY, FORREST, H, THOMAS, EDWIN, J
• Format: Patent
• Language: English; French
• Published: 24.10.2013
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF; TRAPPING

The invention provides compositions and methods for treating cancer with glufosfamide in combination with an inhibitor of sodium-glucose transporter type 2 (SGLT2) to block the uptake of glucose in the proximal tubules of the kidneys to decrease renal toxicity. The invention relates to the fields of biomedicine, pharmacology, and molecular biology. L'invention concerne des compositions et des méthodes de traitement du cancer par du glufosfamide en combinaison avec un inhibiteur du transporteur de sodium-glucose de type 2 (SGLT2) afin de bloquer la capture du glucose dans les tubules proximaux des reins, pour diminuer la toxicité rénale. L'invention concerne les domaines de la biomédecine, de la pharmacologie et de la biologie moléculaire.