SOLID FORMS OF A THIOPHOSPHORAMIDATE NUCLEOTIDE PRODRUG

The present application relates to solid state forms, for example, crystalline forms of 2'-C-methyluridine-5'-(O-phenyl-N-(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate, pharmaceutical compositions that can include one or more solid forms of 2'-C-methyluridine-5'-(O-phenyl-N...

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Main Authors MUDUNURI, PRAVEEN, KULDIPKUMAR, ANUJ, K, NUGENT, WILLIAM, ALOYSIUS, WILLCOX, DAVID, RICHARD, MEDEK, ALES, WALDO, MICHAEL, FERRIS, LORI, ANN, JUNG, YOUNG, CHUN
Format Patent
LanguageEnglish
French
Published 15.05.2014
Subjects
CHEMISTRY
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SUGARS
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Summary:The present application relates to solid state forms, for example, crystalline forms of 2'-C-methyluridine-5'-(O-phenyl-N-(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate, pharmaceutical compositions that can include one or more solid forms of 2'-C-methyluridine-5'-(O-phenyl-N-(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate, and methods of treating or ameliorating diseases and/or conditions with one or more solid forms of 2'-C-methyluridine-5'-(O-phenyl-N-(S)-1-(isopropoxy carbonyl)ethyl)thiophosphoramidate. Also disclosed herein are methods of treating diseases and/or conditions with one or more solid forms of 2'-C-methyluridine-5'-(O-phenyl-N-(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate in combination with one or more other agents. La présente invention concerne des formes à l'état solide, par exemple, des formes cristallines de thiophosphoramidate 2'- C-méthyluridine -5'- (O-phényl-N- (S)-1- (isopropoxycarbonyl) éthyle), des compositions pharmaceutiques qui peuvent comprendre une ou plusieurs formes solides de thiophosphoramidate 2'- C-méthyluridine -5'- (0-phényl-N- (S) -1- (isopropoxycarbonyl) éthyle), et des procédés de traitement ou de diminution de maladies et/ou d'états pathologiques avec une ou plusieurs formes solides de thiophosphoramidate 2'- C-méthyluridine -5'- (O-phényl-N- (S)-1- (isopropoxy carbonyl) éthyle). L'invention concerne également des procédés de traitement de maladies et/ou détats pathologiques avec une ou plusieurs formes solides de thiophosphoramidate 2'- C-méthyluridine -5'- (O-phényl-N- (S)-1- (isopropoxycarbonyl) éthyle) en association avec un ou plusieurs autres agents.
Bibliography:Application Number: WO2013US30267