QUINAZOLINE COMPOUNDS AND THEIR USE IN THERAPY

This invention relates to quinazoline compounds of Formula (I) which are inhibitors of the histone lysine methyltransferase (HKMTase) EZH2, and to uses of such compounds as medicaments, in particular in the treatment of a disease or disorder in which inhibition of EZH2 provides a therapeutic or prop...

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Main Authors SUN, AIMING, SYNDER, JAMES, CHAPMAN-ROTHE, NADINE, FUCHTER, MATTHEW JOHN, LIU, JIN, SRIMONGKOLPITHAK, NITIPOL, BROWN, ROBERT, GANESH, THOTA, CARON, JOACHIM
Format Patent
LanguageEnglish
French
Published 26.09.2013
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:This invention relates to quinazoline compounds of Formula (I) which are inhibitors of the histone lysine methyltransferase (HKMTase) EZH2, and to uses of such compounds as medicaments, in particular in the treatment of a disease or disorder in which inhibition of EZH2 provides a therapeutic or prophylactic effect. La présente invention concerne des composés de quinazoline de formule (I) qui sont des inhibiteurs de l'histone lysine méthyltransférase (HKMT) EZH2 et des utilisations de tels composés comme médicaments, en particulier dans le traitement d'une maladie ou d'un trouble dans lequel l'inhibition d'EZH2 produit un effet thérapeutique ou prophylactique. Formule (I)
Bibliography:Application Number: WO2013GB50689