GLYCOMIMETICS TO INHIBIT PATHOGEN-HOST INTERACTIONS

The present invention relates to novel glycomimetic compounds that are rationally designed to inhibit the binding of various pathogens to cell surface sialylated galactose and methods of use thereof. Specifically sialic acid glycosides and C-glycosides are disclosed that form a lactam ring structure...

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Bibliographic Details
Main Authors YANG, LORETTA, WOODS, ROBERT, J, SMITH, HANNAH, M., K, MURPHY, PAUL, V, HENDEL, JENNIFER
Format Patent
LanguageEnglish
French
Published 21.11.2013
Subjects
CHEMISTRY
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SUGARS
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Summary:The present invention relates to novel glycomimetic compounds that are rationally designed to inhibit the binding of various pathogens to cell surface sialylated galactose and methods of use thereof. Specifically sialic acid glycosides and C-glycosides are disclosed that form a lactam ring structure or a cyclic ether/amine ring structure with the adjacent monosaccharide residue. Cette invention concerne de nouveaux composés glycomimétiques qui sont rationnellement conçus pour inhiber la liaison de divers pathogènes au galactose sialylé à la surface des cellules et des procédés pour les utiliser. Plus spécifiquement, des glycosides d'acide sialique et des C-glycosides qui forment une structure de cycle lactame ou une structure de cycle éther cyclique/amine avec le résidu monosaccharide adjacent sont décrits.
Bibliography:Application Number: WO2013US31238