PROCESS FOR PREPARATION OF DRONEDARONE BY THE USE OF DIBUTYLAMINOPROPANOL REAGENT

The invention relates to a novel process for preparation of dronedarone of formula (I) and pharmaceutically acceptable salts thereof, characterized in that a compound of formula (II) - where L is leaving group - is reacted with compound of formula (III) and the obtained product is isolated and, if d...

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Bibliographic Details
Main Author FRIESZ, ANTAL
Format Patent
LanguageEnglish
French
Published 20.02.2014
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention relates to a novel process for preparation of dronedarone of formula (I) and pharmaceutically acceptable salts thereof, characterized in that a compound of formula (II) - where L is leaving group - is reacted with compound of formula (III) and the obtained product is isolated and, if desired, converted into a pharmaceutically acceptable salt thereof. La présente invention concerne un nouveau procédé de préparation de dronédarone de formule (I) et de ses sels pharmaceutiquement acceptables. L'invention est caractérisée en ce qu'un composé de formule (II), dans laquelle L est un groupe partant, est mis en réaction avec un composé de formule (III), et en ce que le produit obtenu est isolé et, facultativement, converti en un sel pharmaceutiquement acceptable de celui-ci.
Bibliography:Application Number: WO2013IB00915