USE OF TRIFLUOROACETAMIDE FOR N-TERMINAL PROTECTION

This disclosure teaches the novel use of trifluoroacetamide for N-terminal protection. The disclosure also teaches novel compositions and chemical structures associated therewith. These methods and compositions are useful for site-specific methylation of peptide backbone amides, performed, for examp...

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Bibliographic Details
Main Authors TURNER, RUSHIA, LOKEY, SCOTT
Format Patent
LanguageEnglish
French
Published 22.08.2013
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:This disclosure teaches the novel use of trifluoroacetamide for N-terminal protection. The disclosure also teaches novel compositions and chemical structures associated therewith. These methods and compositions are useful for site-specific methylation of peptide backbone amides, performed, for example, to modulate the pharmacokinetic properties of peptide drugs. Cette invention enseigne la nouvelle utilisation de trifluoroacétamide pour une protection d'extrémité N-terminale. L'invention enseigne également de nouvelles compositions et des structures chimiques associées à celles-ci. Ces procédés et compositions sont utiles pour une méthylation de site spécifique d'amides de squelettes peptidiques, effectuée, par exemple, pour moduler les propriétés pharmacocinétiques de médicaments peptidiques.
Bibliography:Application Number: WO2013US26760