MULTI-COMPONENT CHIMERA FOR USE AS A VACCINE AGAINST INFECTION BY LEISHMANIA SPP. IN MAMMALS

• Main Authors: CARRION HERRERO, FCO. JAVIER, DOMINGUEZ BERNAL, GUSTAVO, DE LA FUENTES LOPEZ, RICARDO, ORDEN GUTIERREZ, JOSE ANTONIO
• Format: Patent
• Language: English; French; Spanish
• Published: 01.08.2013
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS; TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE; TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE; VINEGAR; WINE

The present invention relates to a multi-component chimera, HISA70, which comprises the H2A, H2B, H3, H4, A2 and HSP70 from Leishmania infantum. The invention further relates to an immunogenic composition that comprises said multi-component chimera and to the use of said composition in the preparation of a vaccine against Leishmania spp., with a view to conferring protection against leishmaniosis, including cutaneous leishmaniosis and visceral leishmaniosis, in mammals. La presente invención se relaciona con una quimera multicomponente, HISA70, que comprende los genes H2A, H2B, H3, H4, A2 y HSP70 procedentes de Leishmania infantum Así mismo, se relaciona con una composición inmunogénica que comprende dicha quimera multicomponente y con el uso de dicha composición en la elaboración de una vacuna frente a Leishmania spp., para conferir protección frente a la leishmaniosis, incluidas las leishmaniosis cutánea y la leishmaniosis visceral, a mamíferos. La présente invention concerne une chimère multicomposée, HISA70, comprenant les gènes H2A, H2B, H3, H4, A2 et HSP70 provenant de Leishmania infantum. L'invention concerne également une composition immunogène comprenant ladite chimère multicomposée ainsi que l'utilisation de cette composition dans l'élaboration d'un vaccin contre Leishmania spp., en vue d'assurer une protection contre la leishmaniose, y compris la leishmaniose cutanée et la leishmaniose viscérale, chez des mammifères.