SYNTHESIS OF RALTEGRAVIR
The present invention relates to a novel synthetic route for the preparation of raltegravir and pharmaceutically acceptable salts, starting from 2-amino-2- methylpropanenitrile and oxadiazole carbonyl chloride, through the formation of a pyrimidinone intermediate of formula (V). L'invention con...
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| Format | Patent |
| Language | English French |
| Published |
02.10.2014
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| Abstract | The present invention relates to a novel synthetic route for the preparation of raltegravir and pharmaceutically acceptable salts, starting from 2-amino-2- methylpropanenitrile and oxadiazole carbonyl chloride, through the formation of a pyrimidinone intermediate of formula (V).
L'invention concerne une nouvelle voie de synthèse pour préparer du raltégravir et ses sels pharmaceutiqeument acceptables, à partir de 2-amino-2-méthylpropane nitrile et de chlorure d'oxadiazole cabonyle, par formation d'un intermédiaire de pyrimidinone de formule (V). |
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| AbstractList | The present invention relates to a novel synthetic route for the preparation of raltegravir and pharmaceutically acceptable salts, starting from 2-amino-2- methylpropanenitrile and oxadiazole carbonyl chloride, through the formation of a pyrimidinone intermediate of formula (V).
L'invention concerne une nouvelle voie de synthèse pour préparer du raltégravir et ses sels pharmaceutiqeument acceptables, à partir de 2-amino-2-méthylpropane nitrile et de chlorure d'oxadiazole cabonyle, par formation d'un intermédiaire de pyrimidinone de formule (V). |
| Author | MAIKAP, GOLAKCHANDRA SUDARSHAN PATIL, GULABRAO DAGADU SONAWANE, SWAPNIL PANDITRAO PATIL, PANKAJ SHALIKRAO GURJAR, MUKUND KESHAV MEHTA, SAMIT SATISH SHINDE, SHIVNATH BHAUPATIL |
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| Snippet | The present invention relates to a novel synthetic route for the preparation of raltegravir and pharmaceutically acceptable salts, starting from 2-amino-2-... |
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| Title | SYNTHESIS OF RALTEGRAVIR |
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