SYNTHESIS OF RALTEGRAVIR
The present invention relates to a novel synthetic route for the preparation of raltegravir and pharmaceutically acceptable salts, starting from 2-amino-2- methylpropanenitrile and oxadiazole carbonyl chloride, through the formation of a pyrimidinone intermediate of formula (V). L'invention con...
Saved in:
Main Authors | , , , , , , |
---|---|
Format | Patent |
Language | English French |
Published |
02.10.2014
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | The present invention relates to a novel synthetic route for the preparation of raltegravir and pharmaceutically acceptable salts, starting from 2-amino-2- methylpropanenitrile and oxadiazole carbonyl chloride, through the formation of a pyrimidinone intermediate of formula (V).
L'invention concerne une nouvelle voie de synthèse pour préparer du raltégravir et ses sels pharmaceutiqeument acceptables, à partir de 2-amino-2-méthylpropane nitrile et de chlorure d'oxadiazole cabonyle, par formation d'un intermédiaire de pyrimidinone de formule (V). |
---|---|
Bibliography: | Application Number: WO2012IN00835 |