SYNTHESIS OF RALTEGRAVIR

The present invention relates to a novel synthetic route for the preparation of raltegravir and pharmaceutically acceptable salts, starting from 2-amino-2- methylpropanenitrile and oxadiazole carbonyl chloride, through the formation of a pyrimidinone intermediate of formula (V). L'invention con...

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Bibliographic Details
Main Authors SONAWANE, SWAPNIL PANDITRAO, MAIKAP, GOLAKCHANDRA SUDARSHAN, MEHTA, SAMIT SATISH, SHINDE, SHIVNATH BHAUPATIL, PATIL, PANKAJ SHALIKRAO, GURJAR, MUKUND KESHAV, PATIL, GULABRAO DAGADU
Format Patent
LanguageEnglish
French
Published 02.10.2014
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention relates to a novel synthetic route for the preparation of raltegravir and pharmaceutically acceptable salts, starting from 2-amino-2- methylpropanenitrile and oxadiazole carbonyl chloride, through the formation of a pyrimidinone intermediate of formula (V). L'invention concerne une nouvelle voie de synthèse pour préparer du raltégravir et ses sels pharmaceutiqeument acceptables, à partir de 2-amino-2-méthylpropane nitrile et de chlorure d'oxadiazole cabonyle, par formation d'un intermédiaire de pyrimidinone de formule (V).
Bibliography:Application Number: WO2012IN00835