BS AND RRBS SEQUENCING-BASED BIOINFORMATICS ANALYSIS METHOD AND DEVICE

Provided in the present invention are a method and a device for analyzing methylation in a genome by bisulfite sequencing or reduced representation bisulfite sequencing. Also provided in the present invention is a bioinformatics analysis method based on bisulfite sequencing or reduced representation...

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Main Authors XIA, YUDONG, WANG, JUN, YANG, HUANMING, WU, BOXIN, LI, YINGRUI, HUANG, SHUJIA, WU, HONGLONG, WANG, JIAN, RAO, JUNHUA
Format Patent
LanguageChinese
English
French
Published 22.08.2013
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Summary:Provided in the present invention are a method and a device for analyzing methylation in a genome by bisulfite sequencing or reduced representation bisulfite sequencing. Also provided in the present invention is a bioinformatics analysis method based on bisulfite sequencing or reduced representation bisulfite sequencing. The method comprises: detecting DNA methylation, then performing the bioinformatics analysis, wherein the analysis is an analysis for one or more items selected from the following: data output, sequencing fragments alignment, the coverage situation of methylation sites, the methylation level of the methylation sites, the distribution trend of the whole genome methylation data, the whole genome DNA methylation map, the differentially methylated regions, the statistic for the length of insert fragments, and the coverage of CpG sites. La présente invention concerne un procédé et un dispositif pour analyser la méthylation dans un génome par séquençage au bisulfite ou représentation réduite du séq
Bibliography:Application Number: WO2011CN02243