TRIAZOLOPYRIDYL COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITORS

• Main Authors: COOKE, ANDREW, LONDON, CLARE, RATCLIFFE, PAUL, CAI, JAIQIANG, TAYLOR, JERRY ANDREW, XIONG, YUSHENG, CARSWELL, EMMA, SAMANTA, SWAPAN KUMAR, BENNETT, D. JONATHAN, HOYT, SCOTT, B, MACLEAN, JOHN, KULKARNI, BHEEMASHANKAR, A
• Format: Patent
• Language: English; French
• Published: 28.03.2013
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF; TRAPPING

This invention relates to triazolopyridyl compounds of the structural formula: [Formula should be inserted here] or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthase. L'invention concerne des composés triazolopyridyle de formule structurale (I) ou leurs sels pharmaceutiquement acceptables, dans laquelle les variables sont définies dans la description. Les composés de l'invention inhibent sélectivement l'aldostérone synthase. L'invention concerne également des compositions pharmaceutiques comprenant les composés de formule (I) ou leurs sels ainsi que des méthodes pour traiter, soulager ou prévenir des états qui peuvent être traités par inhibition de l'aldostérone synthase.